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JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 4 (109)   -   Decemder, 2023   -   Pages: 46-54
Rodenticides as the basis of deratisation: general characteristics, classification, mechanisms of action, features of application and prospects (review of literature data)
Babii V.F.1, Hlavachek D.O1
1 State Institution "O.M. Marzłeiev Institute for Public Health of the NAMSU", Kyiv

ÓÄĘ: 615.9 : 632.6

ABSTRACT:
The aim of work is to analyze the current state of the use of rodenticides to control rodents in various areas of human activity, as well as prospects for improving rodenticides.

Materials and methods of research: bibliosemantic, bibliographic and analytical methods of research. The research materials were foreign research articles.

Research results and discussion. Various methods are used around the world to directly control rodent populations or reduce the damage caused by them. These methods include physical (traps, barriers), chemical (toxic baits, fumigants, repellents), biological/cultural (resistant plants, crop type, sanitation, habitat manipulation).
The use of chemicals for rodent control has been practiced for almost a century and is common today. Most rodenticides used today are anticoagulants, which prevent blood clotting.
The biological effectiveness of rodent control is determined not only by the toxicity of the rodenticide drug, but also by many other conditions that are closely related to the biological characteristics of the development of rodents. All rodenticides are enteric drugs. The mechanism of toxic effects of drugs in this group is different and is determined by the active substances on the basis of which they are made.
The article presents various approaches to the classification of rodenticides and describes the ways of their impact on target and non-target animal species. The risk and toxicity of the most commonly used rodenticides, which have different chemical compositions and can have a wide range of clinical manifestations, are also assessed. The amount of bait that constitutes a lethal dose depends on the toxicity of the poison and the severity of the person.

Conclusion: among the prospects for the further use of rodenticides, the leading place is occupied by the development of an “ideal rodenticide”, highly toxic to rodents in small quantities, non-toxic to non-target species and allows to avoid fear of the bait in rodents and, accordingly, rejection of it.

KEYWORDS:
rodenticides, deratization, anticoagulants, poisoning
REFERENCES:
1. Aulicky R. Rodents in crop production agricultural systems. Special issue. Agronomy. 2022 Nov 11; 12(11):2813. https://doi.org/10.3390/agronomy12112813
2. Witmer G. Rodents in agriculture: a broad perspective. Agronomy. 2022 Jun 17; 12(6):1458. https://doi.org/10.3390/agronomy12061458
3. Witmer G, Horak K, Moulton R, Baldwin RA. New rodenticides: an update on recent research trials. In: Proceedings of the 15th wildlife damage management conference. 2013: 79-85. https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1163&context=icwdm_wdmconfproc
4. Witmer GW, Eisemann JD. Rodenticide use in rodent management in the United States: an overview. In : Proceedings of the 12th wildlife damage management conference. 2007 : 114-8.
5. Eisemann JD, Moulton R, Witmer G,. The use of forced gas rodent burrow fumigation systems and the potential risk to humans. In : Proceedings of the Vertebrate Pest Conference. 2016; 27. https://doi.org/10.5070/v427110460
6. Desoky A. Rodenticide use in rodent control in upper egypt: an overview. Global Journal of Life Sciences and Biological Research. 2016; (2(2)): 25-7.
7. van den Brink NW, Elliott JE, Shore RF, Rattner BA, editors. Anticoagulant rodenticides and wildlife. Springer International Publishing, Cham; 2018 : 1-9. https://doi.org/10.1007/978-3-319-64377-9
8. Jacob J, Buckle A. Use of Anticoagulant Rodenticides in Different Applications Around the World. In: van den Brink N., Elliott J., Shore R., Rattner B. (eds). Anticoagulant Rodenticides and Wildlife. Emerging Topics in Ecotoxicology. Springer, Cham ; 2018; 5. https://doi.org/10.1007/978-3-319-64377-9_2
9. National Pesticide Information Center. Rodenticides. 2016 Mar. http://npic.orst.edu/factsheets/rodenticides.html
10. Kapoor H, Lohani KR, Lee TH, Agrawal DK, Mittal SK. Animal models of barrett's esophagus and esophageal adenocarcinoma-past, present, and future. Clinical and Translational Science. 2015 Jul 27; 8(6):841-7. https://doi.org/10.1111/cts.12304
11. Markova SO, Kurdil NV, Zinovieva ML, Studzinska YV, Vashchenko LK, Pisochenko KV, Zatsarinska OI, Priyma TV. [Coumarin toxicology: literature review and case study of the 4-hydroxycoumarin derivatives poisoning]. Emergency Medicine. 2020 Sep 1;16(5):7-16. Ukrainian https://doi.org/10.22141/2224-0586.16.5.2020.212218.
12. Thomas S, Varnham K, Havery S. Current Recommended Procedures for UK (bait station) rodent eradication projects. Sandy, Bedfordshire: (Version 4.0) Royal Society for the Protection of Birds; 2017. 41 p.
13. 1.Syahputri DA, Priyambodo S. Flavor ingredients in the rodenticide formulation to improve consumption rate and mortality of house rat (rattus tanezumi L.). IOP Conference Series: Earth and Environmental Science. 2020 Apr 28;468:012005. https://doi.org/10.1088/1755-1315/468/1/012005
14. Baxter MA, Buckle AP, Endepols S, Prescott CV. Anticoagulant rodenticide blood–clotting dose–responses and resistance factors for Tyrosine139Cysteine (Y139C) heterozygous– and homozygous–resistant house mice (Mus musculus). Pest Management Science. 2022 Jul 29. https://doi.org/10.1002/ps.7066
15. Hadler M, Buckle A. Forty five years of anticoagulant rodenticides - past, present and future trends. In: Proceedings of the fifteenth vertebrate pest conference; 1992 Mar 3-5; Newport Beach, California. California : University of California; 1992 :149-55.
16. Saravanan K, Kanakasabai R, Thiyagesan K. Field evaluation of difethialone, a new second generation anticoagulant rodenticide in the rice fields. Indian Journal of Experimental Biology. 2003;(41(6)):655-8.
17. D'Silva C. Rodenticide poisoning. Indian Journal of Critical Care Medicine. 2019;23(4):272-7. https://doi.org/10.5005/jp-journals-10071-23318
18. Lim GB. Warfarin: from rat poison to clinical use. Nature Reviews Cardiology. 2017 Dec 14. https://doi.org/10.1038/nrcardio.2017.172
19. Pitaro M, Croce N, Gallo V, Arienzo A, Salvatore G, Antonini G. Coumarin-Induced hepatotoxicity: a narrative review. Molecules. 2022 Dec 19;27(24):9063. https://doi.org/10.3390/molecules27249063
20. Meerburg BG, Brom FW, Kijlstra A. The ethics of rodent control. Pest Management Science. 2008 Dec; 64(12):1205-11. https://doi.org/10.1002/ps.1623
21. Suárez OV, Cueto GR, Yildiz F. Comparison of efficacy of second-generation anticoagulant rodenticides: effect of active ingredients, type of formulation and commercial suppliers. Cogent Food & Agriculture. 2018 Jan 1; 4(1):1525147. https://doi.org/10.1080/23311932.2018.1525147
22. US EPA. Label review manual, chapter 7: precautionary labeling. Office of Pesticide Programs. 2018. 20 p. https://www.epa.gov/sites/default/files/2018-04/documents/chap-07-mar-2018.pdf
23. Isackson B, Irizarry L.; National Center for Biotechnology Information. Rodenticide Toxicity - StatPearls - NCBI Bookshelf; 2023. https://www.ncbi.nlm.nih.gov/books/NBK554428/
24. King N, Tran MH. Long-Acting anticoagulant rodenticide (superwarfarin) poisoning: a review of its historical development, epidemiology, and clinical management. Transfusion Medicine Reviews. 2015 Oct; 29(4):250-8. https://doi.org/10.1016/j.tmrv.2015.06.002
25. Caravati EM, Erdman AR, Scharman EJ, Woolf AD, Chyka PA, Cobaugh DJ, Wax PM, Manoguerra AS. Long-acting anticoagulant rodenticide poisoning: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology. 2007 Jan; 45(1):1-22. https://doi.org/10.1080/15563650600795487
26. Saraf V, Pande S, Gopalakrishnan U, Balakrishnan D, Menon RN, Sudheer OV, Dhar P, Sudhindran S. Acute liver failure due to zinc phosphide containing rodenticide poisoning: clinical features and prognostic indicators of need for liver transplantation. Indian Journal of Gastroenterology. 2015 Jul; 34(4):325-9. https://doi.org/10.1007/s12664-015-0583-2
27. Laakso S, Suomalainen K, Koivisto S. Literature review on residues of anticoagulant rodenticides in non-target animals. Copenhagen: Nordic Council of Ministers; 2010. 47 p. TemaNord 2010:541.
28. Shore RF., Coeurdassier M. Primary exposure and effects in non-target animals. In: van den Brink N., Elliott J., Shore R., Rattner B. (eds) Anticoagulant Rodenticides and Wildlife. Emerging Topics in Ecotoxicology. Vol. 5. Springer, Cham; 2018 : 135-57. https://doi.org/10.1007/978-3-319-64377-9_6
29. Abernathy EV, Hull JM, Fish AM, Briggs CW. Secondary anticoagulant rodenticide exposure in migrating juvenile red-tailed hawks (buteo jamaicensis) in relationship to body condition. Journal of Raptor Research. 2018 Jun; 52(2):225-30. https://doi.org/10.3356/jrr-17-39.1
30. Nakayama SM, Morita A, Ikenaka Y, Mizukawa H, Ishizuka M. A review: poisoning by anticoagulant rodenticides in non-target animals globally. Journal of Veterinary Medical Science. 2019; 81(2):298-313. https://doi.org/10.1292/jvms.17-0717
31. Rached A, Moriceau MA, Serfaty X, Lefebvre S, Lattard V. Biomarkers potency to monitor non-target fauna poisoning by anticoagulant rodenticides. Frontiers in Veterinary Science. 2020 Dec 23; 7. https://doi.org/10.3389/fvets.2020.616276
32. Regnery J, Friesen A, Geduhn A, Göckener B, Kotthoff M, Parrhysius P, Petersohn E, Reifferscheid G, et al. Rating the risks of anticoagulant rodenticides in the aquatic environment: a review. Environmental Chemistry Letters . 2018 Sep 5;17(1):215-40. https://doi.org/10.1007/s10311-018-0788-6
33. Siers S, Shiels A, Volker S, Rex K. Brodifacoum residues in fish three years after an island-wide rat eradication attempt in the tropical Pacific. Management of Biological Invasions. 2020;11(1):105-21. https://doi.org/10.3391/mbi.2020.11.1.08
34. Ayyad MA, Ali MA, Helmy ET, Soliman UA. Novel triazole derivatives as potential rodenticides against the Norway rat, R. norvegicus: histology, biochemical alternations, and field application. Chemical Papers. 2023 Jun 26. https://doi.org/10.1007/s11696-023-02912-2
35. Quasim MA, Karn AK, Paul S, Hmar EB, Sharma HK. Herbal rodent repellent: a dependable and dynamic approach in defiance of synthetic repellent. Bulletin of the National Research Centre. 2023 Jun 9;47(1). https://doi.org/10.1186/s42269-023-01055-4
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