Home Page   -   Åditorial Board   -   Instructions to autors   -   Archive   -   Contact   -   Journal's Indexing UA   EN


Last issue

¹ 1 (110), 2024


Support

Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 3 (100)   -   September, 2021   -   Pages: 30-37
Folate cycle genetics, level of homocysteine, thyroid and pituitary hormones in the blood among the children from the districts bordering the Chornobyl exclusion zone
Bandazhevskyi Yu.I.1, Dubova N.F.2
1 Ecology and Health Coordination and Analytical Centre, Ivankiv
2 P. L. Shupyk National Medical Academy for Post-Graduate Education, Kyiv

ÓÄÊ: 616-053.7-001.28-06:575:577.164.1:616.153: 577.175.3/4:616.153.478.6:614.876.004.6(477.41)

ABSTRACT:
Objective: The aim of the study was to identify interrelations between the state of folate cycle genetic apparatus and blood levels of homocysteine, thyroid and adenohypophysis hormones in the blood among the children from Ivankivskyi and Poliskyi districts, Kyiv region, bordering the Chornobyl exclusion zone (ÑhEZ).

Methods: Immunochemical, genetic, statistical ones.

Results: We measured blood levels of homocysteine (Hcy), pituitary thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4) in 158 children from Poliskyi district and 178 children from Ivankivskyi district and assessed the state of a genetic system of the folate cycle (FC). The average age of the examined was (15.2 ± 0.9) years old (95% CI 15.0-15.4 years old). Taking into account the FC genotypes, genetic subgroups were formed, they were based on 100% representation of one specific genotype. The laboratory examination was carried out twice: in April and December 2015 (before and after the fires in the ChEZ). It was found out that in the total group of the children, as well as in most of analyzed genetic subgroups, the level of Hcy and thyroid hormones (TG) in the children from Ivankivskyi district was statistically significantly higher than in those from Poliskyi district. At the same time, a direct association between Hcy and TSH was observed in the total group, as well as in most of the genetic subgroups of children from Ivankivskyi district, and this ssociation was absent in the children from Poliskyi district. The blood level of Hcy both in the children from Poliskyi district and in the children from Ivankivskyi district was statistically significantly higher in the subgroup containing only homozygous variants of the T allele of the MTHFR:677 genetic polymorphism in comparison with the subgroups containing neutral C alleles of the same polymorphism. At the same time, there were no differences for TSH, T3 and T4.

Ñonclusions: The analysis enabled to establish a synchronous reaction of metabolic cycles ensuring the metabolism of Hcy and thyroid hormones in the adolescents, regardless of the FC genotypes. Correlation analysis, as well as the results of statistical analysis, indicate that an increase in the level of Hcy in the blood of children induced the synthesis of TSH and T3. The results show a close relationship between thyroid hormone genesis and the metabolism of methionine sulfur-containing amino acids and Hcy. A forest fire, containing long-lived radioactive elements, is the most likely reason for the increase of Hcy level and, as a result, the hormones of the pituitary-thyroid axis in the blood of the children living in the districts, bordering the ChEZ.

KEYWORDS:
homocysteine, folate cycle, thyroid and pituitary hormones, adolescents, radiation contaminated areas
REFERENCES:
1. Bandazhevsky³ Yu.I. and Dubova N.F. Ñomparative Assessment of Metabolic Processes in Children Living in the Areas Affected by the Chîrnobyl Nuclear Power Plant Accident. Dovkillia ta zdorovia (Environment&Health). 2017 ; ¹ 4 : 27-30. https://doi.org/10.32402/dovkil2017.04.027
2. Mc Cully KS. Homocysteine and the Pathogenesis of Atherosclerosis. Expert Review of Clinical Pharmacology. 2015 ; 8 (2) : 211-219. https://doi.org/10.1586/17512433.2015.1010516
3. Lai W.K. and Kan M.Y. Homocysteine-Induced Endothelial Dysfunction. Annals of Nutrition and Metabolism. 2015 ; 67 (1) : 1-12. https://doi.org/10.1159/000437098
4. Ganguly P. and Alam S. Role of Homocysteine in the Development of Cardiovascular Disease. Nutrition Journal. 2015 ; 14 : 6. https://doi.org/10.1186/1475-2891-14-6
5. Polushin A.Yu., Odinak M.M., Yanishevskiy S.N., Golokhvastov C.Yu. and Tsygan N.V. Gipergomotsisteinemiya – prediktor tyazhesti insulta na fone obshirnosti povrezhdeniya mozgovogo veshchestva [Hyperhomocysteinemia is a Predictor of Stroke Severity against the Background of Extensive Damage to the Medulla]. Vestnik Rossiyskoy voyenno-meditsinskoy akademii. 2013 ; 4 (44) : 89-94 (in Russian).
6. Varshney K.K., Gupta J.K. and Mujwar S. Homocysteine Induced Neurological Dysfunctions: A Link to Neurodegenerative Disorders. International Journal of Medical Research & Health Sciences. 2019 ; 8 (4) : 135-146.
7. Keshteli A., Baracos V. and Madsen K. Hyperhomocysteinemia as a Potential Contributor of Colorectal Cancer Development in Inflammatory Bowel Diseases: A Review. World J Gastroenterol. 2015 ; 21 (4) : 1081-1090. https://doi.org/10.3748/wjg.v21.i4.1081
8. Teplyakov A.T., Berezikova E.N., Shilov S.N., Grakova E.V., Torim Yu.Yu., Efremov A.V. et al. Otsenka roli gipergomotsisteinemii i polimorfizma S677T gena metilentetragidrofolat-reduktazy v razvitii khronicheskoy serdechnoy nedostatochnosti [Assessment of the Role of Hyperhomocysteinemia and C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene in the Development of Chronic Heart Failure]. Kardiovaskulyarnaya terapiya i profilaktika. 2016 ; 15 (4) : 22-28 (in Russian). https://doi.org/10.15829/1728-8800-2016-4-22-28
9. Bandazhevsk³y Yu.I. and Dubovaya N.F. Rol genoma folatnogo tsikla v vozniknovenii gipergomotsisteinemii u detey iz rayonov. postradavshikh v rezultate avarii na Chernobylskoy atomnoy elektrostantsii [The Role of the Folate Cycle Genome in the Occurrence of Hyperhomocysteinemia in the Children from the Areas Affected the Accident at the Chernobyl Power Plant]. In : Chornobyl: ekolohiia i zdorovia: naukovo-praktychnyi zbirnyk [Chornobyl: Ecology and Health: Scientific-and-Practical Collected Book]; Yu.I. Bandazhevsky³ (ed.). Ivankiv, Ukraine : PU Koordynatsiinyi analitychnyi tsentr «Ekolohiia i zdorovia» ; Dnipro : Seredniak T.K., 2017 ; 5 : 26-35 (in Russian).
10. Catargi B., Parrot-Roulaud F., Cochet C., Ducassou D., Roger P. and Tabarin A. Homocysteine, Hypothyroidism, and Effect of Thyroid Hormone Replacement. Thyroid. 1999 ; 9 (12) : 1163-1166. https://doi.org/10.1089/thy.1999.9.1163
11. State Institution «National Research Centre for Radiation Medicine of NAMS of Ukraine» ; Radiation Protection Research Institute of the Academy of Technology Sciences of Ukraine. Zahalnodozymetrychna pasportyzatsiia ta rezultaty LVL-monitorynhu v naselenykh punktakh Ukrainy, yaki zaznaly radioaktyvnoho zabrudnennia pislia Chornobylskoi katastrofy. Dani za 2011 r. [General Dosimetric Certification and Results of WBC-Monitoring in the Settlements of Ukraine Suffered from the Radioactive Contamination after Chornobyl Catastrophe]. Êyiv ; 2012; Iss. 14 : 99 ð. (in Ukrainian).
12. Bandazhevsky³ Yu.I. and Dubovaya N.F. Forest Fires in the Chîrnobyl Exclusion Zone and Children’s Health. PI Coordination and Analytical Center «Ecology and Health». Kyiv : Aliant ; 2021: 44 p.
13. Labunska I., Levchuk S., Kashparov V., HoliakaD., Yoschenko L., Santillo D. and Johnston P. Current Radiological Situation in Areas of Ukraine Contaminated by the Chornobyl Accident: Part 2. Strontium-90 Transfer to Culinary Grains and Forest Woods from Soils of Ivankiv District. Environment International. 2021 ; 146 : 106282. DOI: https://doi. org/10.1016/j.envint.2020.106282
14. Kashparov V.A., Mironyuk V.V., Zhurba M.A., Zibtsev S.V., Glukhovskiy A.S. and Zhokova O.M. Radiologicheskiye posledstviya pozhara v Chernobylskoy zone otchuzhdeniya v aprele 2015 goda [Radiological Consequences of the Fire in the Chornobyl Exclusion Zone in April, 2015]. Radiatsionnaya biologiya. Radioekologiya. 2017 ; 57 (5) : 512-527 (in Russian).
15. Sheybak V.M., Lelevich V.V. and Bandazhevsky Yu.I. Free Amino Acids of Blood Plasma and Tissues of Animals after Incorporation of Cesium and Strontium Radionuclides. In : Clinical and Experimental Aspects of the Effect of Incorporated Radionuclides upon the Organism / Ed. By Yu.I. Bandazhevsky³, V.V. Lelevic. Gomel, Belarus ; 1995 : 83-106.
16. Kolpakova A.F., Sharipov R.N. and Volkova O.A. Vliyaniye zagryazneniya atmosfernogo vozdukha vzveshennymi veshchestvami na serdechno-sosudistuyu sistemu [Influence of Air Pollution with Suspended Substances on the Cardiovascular System]. Sibirskiy meditsinskiy zhurnal. 2015 ; 30 (3) : 7-12 (in Russian).
17. Pope C.A., Turner M.C., Burnett R., Jerrett M., Gapstur S.M., Diver W.R. et al. Relationships Between Fine Particulate Air Pollution, Cardiometabolic Disorders and Cardiovascular Mortality. Circ. Res. 2015 ; 116 (1) : 108-115. https://doi.org/10.1161/CIRCRESAHA.116.305060
18. Park S.K., O’Neill M.S., Vokonas P.S., Sparrow D., Spiro A. 3-rd, Tucker K.L. et al. Traffic-Related Particles are Associated with Elevated Homocysteine. The VA Normative Aging Study. Am. J. Respir. Crit. Care Med. 2008 ; 178 : 283-289. https://doi.org/10.1164/rccm.200708-1286OC
Designed by: IPH NAMSU © Environment & Health, 2006-2024. All rights reserved.
Use of text and graphic materials of the site is allowed only upon written permission of the editoral board.