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1 (106), 2023


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Edition of the journal is supported partially by the grant of the Fogarty International Center (FIC) of the National Institute of Health and Illinois University, Chicago.

JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 1 (106)   -   MARCH, 2023   -   Pages: 51-57
Lonzabac GA biocide standardization in air based on marker volatile compound
Turkina V.A.1, Tretiakova O.V.2, Kuzminov B.P.1, Zhuk S.Sh.1
1 Danylo Halytsky Lviv National Medical University, Lviv
2 State Enterprise Ukrainian Research Institute of Transport Medicine of the Ministry of Health of Ukraine, Odesa

ABSTRACT:
Lonzabac GA (active ingredient cocopropylenediamineguanidine acetate) is used as basic component in manufacturing surface and medical instrument disinfectants. In Ukraine, disinfectants are subject to sanitary standardization and obtaining of marketing authorization.
Given that the active ingredient Lonzabac GA is non-volatile, the question came up of detecting volatile compounds that can get into the air during its use, with subsequent establishment of a marker compound to be used to monitor the air quality.

The objective of this paper was to study the toxicity of LONZABAC GA at laboratory animals with various routes of exposure as part of sanitary standardization and to justify the drug administration standard based on marker volatile compound. To this end the sanitary and chemical, toxicological, and statistical research methods were used.

Results: Lonzabac GA classifies as hazard class 3 in terms of acute oral toxicity. It has no skin resorptive effect. Lonzabac GA has dermal and mucous membranes irritating action. Significant cumulative activity. It cause no body sensitization. Lonzabac GA, when used as disinfectant component, does not form drug aerosol, instead, an isopropyl alcohol migrates from the drug into the air. No L50 was reached in acute ingestion experiment. The experimental animals showed no clinical signs of intoxication, changes in biochemical and hematological parameters during chronic inhalation study.

Conclusions: Therefore, it is advisable to monitor air quality both during manufacture and use of Lonzabac GA based on concentration of marker compound isopropyl alcohol.

KEYWORDS:
Lonzabac GA, cocopropylenediamineguanidine acetate, toxicity studies, standardization
REFERENCES:
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