Objective: The intent of the work reported here was to analyze the literary data on the production methods, structure and toxic effects of titanium dioxide nanoparticles. Based on the data of the developer, the structure and physico-chemical characteristics were analysed, the acute toxicity and local action of titanium dioxide nanoparticles were investigated.

Methods: Hygienic, toxicological, bibliographic, analytical methods were applied in the work.

Results: Titanium dioxide nanopowder with photocatalytic effect is practically monodisperse, the average size of the particles is 10 nm, it has a mesoporous structure, contains soft conglomerates from 50 nm to 500 nm, its specific surface area is 57.3 m2/g. Titanium nanodioxide, obtained by thermal decomposition, refers to low-toxic and low-hazard substances, DL50 is more than 5000 mg/kg at intraperitoneal administration to mice. This nanopowder does not irritate the skin and the eye mucous membrane of the rabbits. According to the literature, it has been determined that under chronic exposure to TiO2 nanoparticles in the laboratory animals, the nanoparticles accumulate and contribute to tissue damage in the liver, kidneys, lungs, spleen. In particular, they affect lipid peroxidation and significantly alter the expression of the genes that are responsible for circadian rhythms, metabolic processes and apoptosis.

nanoparticles, nanopowder, titanium dioxide, toxicology, hygiene.

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