|Environment & Health||ISSN: 2077-7477 eISSN: 2077-7485
No: 2 (95) - June, 2020 - Pages: 70-79
Ovarian cancer incidenceand effect of environmental chemical pollution on its formation (analysis of literary data)
Chernychenko I.O.1, Balenko N.V.1, Lytvychenko O.M.1, Babii V.F.1, Hlavachek D.O.1, Kondratenko O.Ye.1
1 State Institution "O.M. Marz³eiev Institute for Public Health of the NAMSU"
Background: Currently, ovarian cancer (OC) is one of the most common malignant diseases in women with a tendency to continuing growth worldwide and a leading cause of death from gynecologic forms of cancers. Chemical contamination of the environment, including substances that have hormonal properties and injury the endocrine system, so-called endocrine disruptors (ED), is suggested to be one of the factors that increase OC incidence.
Objective: We analyzed the literary data concerning the OC incidence and the impact of the environmental chemical pollution on its formation.
Results: The analysis of the literature indicates a relatively small number of studies, especially epidemiological, concerning the connection of environmental chemicals with the incidence of OC. Epidemiological studies have shown that not only typical ED, such as polychlorinated biphenyls and pesticides (atrazine, diazinon, methoxychlor), but also other carcinogenic for human chemical factors (smoking, asbestos) have affected the increase of OC incidence.
Numerous experimental studies have shown that other pesticides and ED caused the hormonal disbalances and carcinogenesis-related effects, realized through mechanisms and signaling pathways dependent on endogenous hormones, which can lead to development and progression of OC. The ED exposures in the early period of development (in utero, neonatal) were established to cause the epigenetic effects, ovarian development disorders and proliferative-hyperplastic changes that relate to precancerous states in the animals. Epigenetic abnormalities in the animals’ ovaries are especially dangerous due to the possible formation of phenotypes sensitive to the development of cancer and their transgenerational transmission to the next generations.
Presented data suggest a significantly larger number of the ED, participating in increase of the risk of OC, which, in addition to pesticides, include a number of wide-spread ED associated with the production and use of consumer goods.
The results of the analysis confirms that OC is a topical and significant ecological, hygienic and social problem that requires the further investigations and solution of the issues related to the protection of the population from the harmful effects of the environmental chemical pollution.
ovarian cancer, incidence, chemical pollution
2. Stewart B.W. and Wild C.P. (eds). World Cancer Report. Lyon: JARÑ Press ; 2014 : 630 p.
3. Gore A.C., Chappell V.A., Fenton S.E. et al. Executive Summary to EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr. Rev. 2015 ; 36 (6) : 593-602. DOI: https://doi.org/10.1210/er.2015-1093
4. Rodgers K.M., Udesky J.O., Rudel R.A. and Brody J.G. Environmental Chemicals and Breast Cancer: An Updated Review of Epidemiological Literature Informed by Biological Mechanisms. Environ. Res. 2018 ;160 : 152-182. DOI: https://doi.org/10.1016/j.envres.2017.08.045
5. Mallozzi M., Leone C., Manurita F. et al. Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies. Int. J. Environ. Res. Public Health. 2017 ; 14 (3) : 334-356. DOI: https://doi.org/10.3390/ijerph14030334
6. Samtani R., Sharma N. and Garg D. Effects of Endocrine-Disrupting Chemicals and Epigenetic Modifications in Ovarian Cancer: A Review. Reprod. Sci. 2017 ; 25 (1) : 7-18. DOI: https://doi.org/10.1177/1933719117711261
7. Serdiuk À.Ì., Bazyka D.À. and Òðîíüêo M.D. (eds.). Natsionalnyi ohliad «Endokrynni ruinivnyky v Ukraini: stan problemy ta shliakhy yii vyrishennia» [National Review "Endocrine Disruptors in Ukraine: the State of the Problem and Ways to Solve it"]. Kyiv : Medinform ; 2018 : 156 p. (in Ukrainian).
8. Baskov À.Ya. and Tulenkov N.V. Metodologiya nauchnogo issledovaniya [Research Methodology]. Kyiv : MFUP ; 2004 ; 215 p. (in Russian).
10. Salehi F., Dunfield L., Phillips K.P. et al. Risk Factors for Ovarian Cancer: an Overview with Emphasis on Hormonal Factors. J. Toxicol. Environ. Health. 2008 ; 11 (3-4) : 301-321. DOI: https://doi.org/10.1080/10937400701876095
11. Morgan M., Deoraj A., Felty Q., Yoo Ch. and Roy D. Association between Exposure to Estrogenic Endocrine Disruptors – Polychlorinated Biphenyls, Phthalates, and Biosphenol A and Gynecologic Caccers – Cervical, Ovarian, Uterine Cancers. Carcinogenesis & Mutagenesis. 2016 ; 7: 4. DOI: https://doi.org/10.4172/2157-2518.1000275
12. Di Donato M., Cernera G., Giovannelli P., Galasso G., Bilancio A. et al. Resent Advances on Biosphenol-A and Endocrine Disruptor Effects on Human Prostate Cancer. Mol Cell Endocrinol. 2017 ; 457 : 35-42. https://doi.org/10.1016/j.mce.2017.02.045
13. Gao H., Yang B.J., Li N., Feng L.M., Shi X.Y., Zhao W.H. and Liu S.J. Biosphenol A and Hormone-Associated Cancers: Current Progress and Perspectives. Medicine (Baltimoe). 2015 ; 94 (1) : 1-8. DOI: https://doi.org/10.1097/MD.0000000000000211
14. Beral V., Gaitskell K., Hermon C. et al. Menopausal Studies of Ovarian Cancer Risk: Individual Participant Meta-Analysis of 52 Epidemiological Studies. Lancet. 2015 ; 385 (9980) : 1835-1842. DOI: https://doi.org/10.1016/S0140-6736(14)61687-1
17. Calafat A.M., Ye X., Wong L.Y., Reidy J.A. and Needham L.L. Exposure of the U.S. Population to Biosphenol A and 4-Tertiary-Octylphenol: 2003-2004. Environ Health. 2008 ; 64 : 17-29. DOI: https://doi.org/10.1289/ehp.10753
18. Woodruff T.J., Zota A.R. and Schwartz J.M. Environmental Chemicals in Pregnant Women in the United States: NHANES 2003-2004. Environ Health Perspect. 2011 ; 119 : 878-885. DOI: https://doi.org/10.1289/ehp.1002727
19. Silva M.J., Barr D.B., Reidy J.A., Malek N.A., Hodge C.C. et al. Urinary Levels of Seven Phthalate Metabolites in the U.S. Population from the National Health and Nutrition Examination Survery (NHANES) 1999-2000. Environ Health Perspect. 2004 ; 112 : 331-338. DOI: https://doi.org/10.1289/ehp.6723
20. Nam-Hee Kang, Kyung-A Hwang, Tae-Hee Kim et al. Induced Growth of BG-1 Ovarian Cancer Cells by 17â-Estradiol or Various Endocrine Disrupting Chemicals Was Reversed by Resveratrol via Downregulation of Cell Cycle Progression. Molecular Medicine Reports. 2012 ; 6 : 151-156.
21. Park S.H., Kim K.Y., An B.S. et al. Cell Growth of Ovarian Cancer Cells is Stimulated by Xenoestogens an Estrogendepent Pathway, but Their Stimulation of Cell Growth Appears Not to be Involved in the Activation of the Mitogen-Activated Protein Kinases ERK-1. J. Reprod. Dev. 2009 ; 55(1) : 23-29. DOI: https://doi.org/10.1262/jrd.20094
22. Dogan S. and Simsek T. Possible Relationship Between Endocrine Disrupting Chemicals and Hormone Dependent Gynecologic Cancers. Med Hipotheses. 2016 ; 92 : 84-87. DOI: https://doi.org/10.1016/j.mehy.2016.04.041
25. Clapp R.W., Jacobs M.M. and Loechler E.L. Environmental and Occupational Causes of Cancer New Evidence, 2005-2007. Rev Environ Health. 2008 ; 23 (1) :1-37. DOI: https://doi.org/10.1515/REVEH.2008.23.1.1
27. Del Pup L., Mantovani A., Cavaliere C. et al. Carcinogenetic Mechanisms of Endocrine Disruptors in Female Cancers (Review). Oncol. Rep. 2016 ; 36 (2) : 603-12. DOI: https://doi.org/10.3892/or.2016.4886
28. Karoutsou E., Karoutsos P. and Karoutsos D. Adverse Effects on Female Human Reproductive Health from Exposure to Endocrine Disruptors: Focus on Endometrial Lesions. 2016. DOI: https://doi.org/10.21767/2472-1158.100033
29. Lerro C.C., Koutros S., Andreotti G. et al. Organophosphate Insecticide Use and Cancer Incidence Among Spouses of Pesticide Applicators in the Agricultural Health Study. Occup. Environ. Med. 2015 ; 72 (10) : 736-744. DOI: https://doi.org/10.1136/oemed-2014-102798
30. Kim J.Y., Yi B.R., Go R.E. et al. Methoxychlor and Triclosan Stimulates Ovarian Cancer Growth by Regulating Cell Cycle- and Apoptosis-Related Genes Via an Estrogen Receptor-Dependent Pathway. Environ. Toxicol. Pharmacol. 2014 ; 37 (3) ; 1264-1274. DOI: https://doi.org/10.1016/j.etap.2014.04.013
31. Hall J.M. and Korach K.S. Endocrine Disrupting Chemicals Promote the Growth of Ovarian Cancer Cells Via the ER-CXCL4 Signaling Axis. Mol Carcinog. 2013 ; 52(9) : 715-725. DOI: https://doi.org/10.1002/mc.21913
32. Ventura C., Nieto M.R., Bourguignon N. et al. Pesticide Chlorpyrifos Acts as an Endocrine Disruptor in Adult Rats Causing Changes in Mammary Gland and Hormonal Balance. J. Steroid Biochem. Mol. Bio. 2016 ;156 : 1-9. DOI: https://doi.org/10.1016/j.jsbmb.2015.10.010
33. Chernychenko I.O., Balenko N.V., Lytvychenko O.M., Babii V.F., Hlavachek D.O. and Kondratenko O.Ye. Zakhvoriuvanist na rak molochnoi zalozy i rol khimichnykh zabrudniuvachiv dovkillia (analiz danykh literatury) [The Incidence of Breast Cancer and the Role of Chemical Pollutants of the Environment (Analysis of the Literature)]. Dovkillia ta zdorovia (Environment&Health). 2019 ; ¹ 3 : 52 – 60 (in Ukrainian). DOI: https://doi.org/10.32402/dovkil2019.03.052
34. Chernychenko I.O., Balenko N.V., Lytvychenko O.M., Babii V.F., Hlavachek D.O. and Kondratenko O.Ye. Zakhvoriuvanist na rak peredmikhurovoi zalozy ivplyv na yii formuvannia khimichnoho zabrudnennia navkolyshnoho seredovyshcha [The Incidence of Prostate Cancer and the Impact of Chemical Pollution of the Environment on its Formation]. Dovkillia ta zdorovia (Environment&Health). 2020 : 1 : 64-75 (in Ukrainian). DOI: https://doi.org/10.32402/dovkil2020.01.064
35. Park M.A., Hwang K.A., Lee H.R. et al. Benzophenone-1 Stimulated the Growth of BG-1 Ovarian Cancer Cell by Cell Cycle Regulation Via an Estrogen Receptor Alphamediated Signaling Pathway in Cellular and Xenograft Mouse Models. Toxicology. 2013 ; 305 : 41-48. https://doi.org/10.1016/j.tox.2012.12.021
36. Trisomboon J., Li C., Suzuki A. et al. 4-Nitro-3- Phenylpenol Has Both Androgenic and Antiandrogenic-Like Effect in Rats. J. Reprod. Dev. 2015 ; 61(2) :134-137. DOI: https://doi.org/10.1262/jrd.2014-110
37. Cogliano V.J., Baan R., Straif K. et al. Preventable Exposures Associated with Human Cancers. J. Natl Cancer Inst. 2011 ; 103(24) :1827 – 1839. DOI: https://doi.org/10.1093/jnci/djr483
38. IARC Monographs on the Evaluation of Carcinogenic Ricks to Humans, Volume 100E: Personal Habits and Indoos Combustions. Lyon, France : IARC; 2012 : 43-319.
39. Balenko N.V., Tsymbaliuk S.M., Chernichenko I.O. and Ostash O.M. Pro mozhlyvi mekhanizmy vplyvu zabrudnen atmosfery benz(a)pirenom na formuvannia zakhvoriuvanosti naselennia na rak shchytopodibnoi zalozy [On Possible Mechanisms of the Influence of Benz(a)pyrene Atmosphere Pollution on Formation of Thyroid Cancer Incidence in the Population]. Dovkillia ta zdorovia (Environment&Health). 2016 ; 1 : 4-8 (in Ukrainian).
40. IARC Monographs on the Evaluation of Carcinogenic Ricks to Humans, Volume 100Ñ: Arsenic, Metals, Fibres and Dusts. Lyon, France: IARC; 2012 : 219- 309. 41.Cramer D.W., Vitonis A.F., Terry K.L. et al. The Association Between Tale Use and Ovarian Cancer. A Retrospective Case Control Study in Two US States. Epidemiology. 2016 ; 27 (3) : 334-346. 42. Zama A.M. and Uzumcu M. Epigenetic Effects of Endocrine-Disrupting Chemicals on Female Reproduction: an Ovarian Perspective. Front. Neuroendocrinol. 2010 ; 31 : 420-439. 43. Uzumcu M., Zama A.M. and Oruc E. Epigenetic Mechanisms in the Actions of Endocrine-Disrupting Chemicals: Gonadal Effects and Role in Female Reproduction. Reprod Domest Anim. 2012 ; 47(4) : 338-347. 44. Zhang X., Ho S.M. Epigenetics Meets Endocrinology. J Mol Endocrinol. 2011 ; 46(1) : 11-32.