|Environment & Health||ISSN: 2077-7477 eISSN: 2077-7485
No: 4 (105) - Decemder, 2022 - Pages: 64-70
Results of the study of the possible influence of a live active culture of lactobacillus plantarum on the indicators of lipid metabolism in laboratory rats
Ostanina N.1, Hryhorenko L.1, Stepanchuk S.1, Ocheretianŗ N.1, Tomashevska L.1, Balenko N.1
1 State Institution "O.M. Marz≥eiev Institute for Public Health of the NAMSU", Kyiv
Objective: Study of the effect of a dietary supplement (DS), which includes a live active culture of Lactobacillus plantarum and policonazole, on lipid metabolism in rats.
Results: The conducted tests revealed the dependence of changes in lipid metabolism in the body of experimental animals on the diet, intake of the studied DD or a well-known synthetic hypolipedemic drug (WSHD) and the timing of their use. Thus, enhanced nutrition of animals of all experimental groups for 45 days led to the development of obesity, as evidenced by an increase in the level of triglycerides, cholesterol, low density lipoproteins (LDL) and high density lipoproteins (HDL).The replacement of enhanced nutrition with the usual one and the simultaneous take them of DS or WSHD contributed to a significantly faster decrease in the levels of the studied parameters compared to those groups of animals that were only on the usual diet.
Conclusions: It was found that the transfer of experimentally obeserats to a normal diet and the intake them of DS and/or WSHD contributed to a significant decreasein triglycerides and cholesterol, as well as the restoration of LDL and HDL levels to the values of intact animals. It was shown that the studied DS can activate metabolic processes in the body, in particular, lipid metabolism
Dietary supplement, live active culture of Lactobacillus plantarum, cholesterol, triglycerides, low and high density lipoproteins, experimental animals
3. Shchorichna dopovid pro stan zdorovia naselennia Ukrainy, sanitarno-epidemichnu sytuatsiiu ta rezultaty diialnosti systemy okhorony zdorovia Ukrainy. 2014 rik [Annual Report about Healthís State of the Ukrainian Population, the Sanitary-Epidemic Situation and the Results of the Ukrainian Health Care Systemís Activity. 2014]. Ministry of Health of Ukraine ; Ukrainian Institute of Strategic Researches. Kyiv ; 2015 : 460 p. (in Ukrainian).
4. Doklinicheskie issledovaniya lekarstvennykh sredstv (metodicheskie rekomendatsii) [Preclinical Studies of Drugs (Guidelines)]. Stefanov ņ.V. (Ed.). Kiev : Avitsenna ; 2002 : 568 p. (in Russian).
5. Kovalenko V.M., Stefanov O.V., Maksymov Yu.M. and Trakhtenberh I.M. Eksperymentalne vyvchennia toksychnoi dii potentsiinykh likarskykh zasobiv: metodychni rekomendatsii [Experimental Study of Potential Medicinal Productsí Toxic Effect: Methodical Recommendations]. Kyiv ; 2000 : 43 p. (in Ukrainian).
6. Antomonov M.Yu. Matematicheskaya obrabotka i analiz mediko-biologicheskikh dannykh [Mathematical Processing and Analysis of Biomedical Data]. Kiev ; 2006 : 558 (in Russian).