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JOURNAL

ISSN 2077-7477 (Print)
ISSN 2077-7485 (Online)

A journal "Dovkillia ta zdorovia" (Environment & Health) publishes the articles on the problems in the field of medical ecology, hygiene, health protection and ecological safety.

Founder of the Journal:
State Institution "O.M. Marzeiev Institute for Hygiene and Medical Ecology of the National Academy of Medical Sciences of Ukraine"

Frequency of publication:
quarterly

Environment & HealthISSN: 2077-7477 eISSN: 2077-7485
No: 4 (105)   -   Decemder, 2022   -   Pages: 64-70
Results of the study of the possible influence of a live active culture of lactobacillus plantarum on the indicators of lipid metabolism in laboratory rats
Ostanina N.1, Hryhorenko L.1, Stepanchuk S.1, Ocheretianŗ N.1, Tomashevska L.1, Balenko N.1
1 State Institution "O.M. Marz≥eiev Institute for Public Health of the NAMSU", Kyiv

ABSTRACT:
Objective: Study of the effect of a dietary supplement (DS), which includes a live active culture of Lactobacillus plantarum and policonazole, on lipid metabolism in rats.

Results: The conducted tests revealed the dependence of changes in lipid metabolism in the body of experimental animals on the diet, intake of the studied DD or a well-known synthetic hypolipedemic drug (WSHD) and the timing of their use. Thus, enhanced nutrition of animals of all experimental groups for 45 days led to the development of obesity, as evidenced by an increase in the level of triglycerides, cholesterol, low density lipoproteins (LDL) and high density lipoproteins (HDL).The replacement of enhanced nutrition with the usual one and the simultaneous take them of DS or WSHD contributed to a significantly faster decrease in the levels of the studied parameters compared to those groups of animals that were only on the usual diet.

Conclusions: It was found that the transfer of experimentally obeserats to a normal diet and the intake them of DS and/or WSHD contributed to a significant decreasein triglycerides and cholesterol, as well as the restoration of LDL and HDL levels to the values of intact animals. It was shown that the studied DS can activate metabolic processes in the body, in particular, lipid metabolism

KEYWORDS:
Dietary supplement, live active culture of Lactobacillus plantarum, cholesterol, triglycerides, low and high density lipoproteins, experimental animals
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